Target Validation Information
TTD ID	T92828
Target Name	Endothelin B receptor (EDNRB)
Type of Target	Successful
Drug Potency against Target	Bosentan	Drug Info	IC50 = 38~152 nM
	Ac-bhg-F-N-Y-Y-W	Drug Info	IC50 = 4300 nM
	Ac-w-F-F-N-Y-Y-W	Drug Info	IC50 = 14000 nM
	Bhg-F-N-Y-Y-W	Drug Info	IC50 = 13000 nM
	BMS-193884	Drug Info	Ki = 18700 nM	[1]
	IRL-1722	Drug Info	Ki = 16 nM
	IRL-1841	Drug Info	Ki = 36 nM
	IRL-2500	Drug Info	Ki = 1 nM
	Linear peptide of RES-701-1	Drug Info	IC50 = 5000 nM
	PD-155080	Drug Info	IC50 = 4550 nM
	PD-163140	Drug Info	IC50 = 1800 nM
	RES-701-1	Drug Info	IC50 = 10 nM
	Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Val-Tyr-Phe-Cys)	Drug Info	IC50 = 1700 nM
	Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Val-Tyr-Phe-Cys)	Drug Info	IC50 = 1700 nM
	W-F-F-N--Y-Y-W	Drug Info	IC50 = 15000 nM
References
REF 1	Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET... J Med Chem. 2000 Aug 10;43(16):3111-7.

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