Target Validation Information
TTD ID	T92403
Target Name	Sodium/hydrogen exchanger 3 (SLC9A3)
Type of Target	Successful
Drug Potency against Target	CARIPORIDE	Drug Info	IC50 = 26 nM	[2]
	ENIPORIDE	Drug Info	IC50 = 8 nM	[2]
	HOE-694	Drug Info	IC50 = 130 nM	[1]
	N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine	Drug Info	IC50 = 270 nM	[1]
	N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine	Drug Info	IC50 = 210 nM	[1]
	N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine	Drug Info	IC50 = 180 nM	[1]
	N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine	Drug Info	IC50 = 380 nM	[1]
	N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine	Drug Info	IC50 = 140 nM	[1]
	N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine	Drug Info	IC50 = 150 nM	[1]
References
REF 1	(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34.
REF 2	Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47.

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