| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T92124 | ||||
| Target Name | OX40L receptor (CD134) | ||||
| Type of Target |
Clinical trial |
||||
| Action against Disease Model | AMG 386 | Drug Info | Blockade of interactions between OX40 on Th2 cells and OX40 ligand (OX40L) on TSLP-activated DCs using an OX40L-specific monoclonal antibody, inhibited Th2 cell-mediated immune responses in both mouse and nonh uMan primate models of allergic inflammation. | [1] | |
| References | |||||
| REF 1 | OX40-OX40L interactions: a promising therapeutic target for allergic diseases J Clin Invest. 2007 Dec;117(12):3655-7. | ||||
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