| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T92076 | ||||
| Target Name | Extracellular calcium-sensing receptor (CASR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Cinacalcet | Drug Info | IC50 = 28 nM | [3] | |
| 2-Furan-2-yl-3-phenethyl-3H-quinazolin-4-one | Drug Info | IC50 = 3500 nM | [2] | ||
| 3-Phenethyl-2-phenyl-3H-quinazolin-4-one | Drug Info | IC50 = 14000 nM | [1] | ||
| References | |||||
| REF 1 | 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60. | ||||
| REF 2 | Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones. Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40. | ||||
| REF 3 | Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35. | ||||
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