| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T92035 | ||||
| Target Name | Hepatitis C virus Internal ribosome entry site messenger RNA (HCV IRES mRNA) | ||||
| Type of Target |
Discontinued |
||||
| Action against Disease Model | ISIS 14803 | Drug Info | ISIS 14803 is a phosphorothioate oligodeoxynucleotide that is complementary to the HCV translation initiation region within the internal ribosome entry site (IRES). ISIS 14803 can reduce HCV RNA in immortalized h uMan hepatocytes expressing a portion of the HCV genome | [1] | |
| References | |||||
| REF 1 | A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients. J Hepatol. 2006 Jan;44(1):88-96. | ||||
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