Target Validation Information
TTD ID T88338
Target Name Bacterial 23S ribosomal RNA (Bact 23S rRNA)
Type of Target
Successful
Drug Potency against Target Linezolid Drug Info IC50 = 0.6 mcg/ml [2]
Action against Disease Model Macrolides Drug Info IC50 on translation in Staphylococcus aureus cells: 200 ng/mL [1]
References
REF 1 A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus. J Antimicrob Chemother. 2001 Oct;48(4):573-7.
REF 2 Bacterial ribosomal subunit assembly is an antibiotic target. Curr Top Med Chem. 2003;3(9):929-47.

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