| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T86057 | ||||
| Target Name | Urate anion exchanger 1 (URAT1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Lesinurad | Drug Info | EC50 = 5000 nM | ||
| MORIN | Drug Info | IC50 = 18000 nM | [1] | ||
| Action against Disease Model | Lesinurad | Drug Info | We investigated the effect of URAT-1 inhibitor losartan (0.2 mM) on K562 cell line | ||
| References | |||||
| REF 1 | Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) express... Drug Metab Dispos. 2007 Jun;35(6):981-6. | ||||
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