Target Validation Information
TTD ID	T85616
Target Name	Thioredoxin (TXN)
Type of Target	Clinical trial
Drug Potency against Target	PX-12	Drug Info	Ki = 0.5 nM	[1]
Action against Disease Model	PX-12	Drug Info	The disulfides inhibited the thioredoxin dependent proliferation of MCF-7 breast cancer cells with ICso values of 1.2 pM, respectively Based on previous studies PX-12 has IC50 value of about 1.2FM.
References
REF 1	Dopamine D5 receptors: a challenge to medicinal chemists. Mini Rev Med Chem. 2008 Sep;8(10):976-95.

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