| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T84581 | ||||
| Target Name | Cytoplasmic thioredoxin reductase (TXNRD1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | 3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide | Drug Info | IC50 < 12500 nM | [2] | |
| 4,6-dinitrobenzo[c][1,2,5]thiadiazole | Drug Info | IC50 = 2000 nM | [1] | ||
| Bis(2,4-dinitrophenyl)sulfane | Drug Info | IC50 = 4000 nM | [1] | ||
| References | |||||
| REF 1 | Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. | ||||
| REF 2 | Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schis... J Med Chem. 2009 Oct 22;52(20):6474-83. | ||||
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