Target Validation Information
TTD ID	T82739
Target Name	Plasma kallikrein (KLKB1)
Type of Target	Successful
Drug Potency against Target	(3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone	Drug Info	IC50 = 5700 nM	[2]
	(3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone	Drug Info	IC50 = 6100 nM	[2]
	(3-nitro-1H-pyrazol-1-yl)(phenyl)methanone	Drug Info	IC50 = 18800 nM	[2]
	(4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone	Drug Info	IC50 = 6200 nM	[2]
	1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide	Drug Info	IC50 = 12300 nM	[2]
	D-Pro-Phe-Arg chloromethyl ketone	Drug Info	IC50 = 31 nM	[3]
	ZK-810388	Drug Info	Ki = 37 nM	[1]
	ZK-814048	Drug Info	Ki = 1000 nM	[1]
References
REF 1	Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80.
REF 2	N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38.
REF 3	Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80.

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