| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T82146 | ||||
| Target Name | Retinoic acid receptor gamma (RARG) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Tazarotene | Drug Info | EC50 = 39 nM | [2] | |
| Action against Disease Model | Tazarotene | Drug Info | IC50 on differentiation marker MRP-8 in normal h uMan keratinocytes: 7nM | [1] | |
| References | |||||
| REF 1 | Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes. Cell Growth Differ. 1999 Apr;10(4):255-62. | ||||
| REF 2 | Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: insight into the mechanism of retinoid action in psoriasis. Cell Growth Differ. 1996 Dec;7(12):1783-91. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.