Target Validation Information
TTD ID	T81015
Target Name	Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF)
Type of Target	Literature-reported
Drug Potency against Target	6-amino-uridine monophosphate	Drug Info	Ki = 840 nM	[1]
	6-aza-uridine monophosphate	Drug Info	Ki = 12400 nM	[1]
	Xanthosine-5'-monophosphate disodium salt	Drug Info	Ki = 400 nM	[2]
References
REF 1	Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem. 2006 Aug 10;49(16):4937-45.
REF 2	Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase. J Med Chem. 2008 Feb 14;51(3):432-8.

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