| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T78892 | ||||
| Target Name | ITGA4 messenger RNA (ITGA4 mRNA) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | MK-0668 | Drug Info | IC50 = 0.15 nM | [2] | |
| TR-14035 | Drug Info | IC50 = 61 nM | [1] | ||
| References | |||||
| REF 1 | 2,3-Diphenylpropionic acids as potent VLA-4 antagonists. Bioorg Med Chem Lett. 2005 Jan 3;15(1):217-20. | ||||
| REF 2 | Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalan... Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. | ||||
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