| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T78656 | ||||
| Target Name | 5-HT 1F receptor (HTR1F) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | LY-334370 | Drug Info | Ki = 1.6 nM | [2] | |
| WAY-466 | Drug Info | Ki = 17.8 nM | [1] | ||
| References | |||||
| REF 1 | Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. | ||||
| REF 2 | Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. | ||||
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