Target Validation Information
TTD ID	T78356
Target Name	Thromboxane-A synthase (TBXAS1)
Type of Target	Clinical trial
Drug Potency against Target	CGS-13080	Drug Info	IC50 = 3.2 nM	[1]
	CGS-22652	Drug Info	IC50 = 2 nM
	ONO-1581	Drug Info	IC50 = 3000 nM
Action against Disease Model	NV-52	Drug Info	NV-52 selectively inhibits TXS in vitro in physiological relevant concentrations, causing a reduction in thromboxane B(2) of </= 40% in association with an increase in prostaglandin E(2). NV-52 is effective in suppressing colonic inflammation in a murine model of inflammatory bowel disease.	[2]
References
REF 1	Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors. J Med Chem. 1985 Feb;28(2):164-70.
REF 2	Nv-52: a novel thromboxane synthase inhibitor for the treatment of inflammatory bowel disease. Expert Opin Investig Drugs. 2007 Aug;16(8):1255-66.

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