Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T76059 | ||||
Target Name | FK506-binding protein 1A (FKBP1A) | ||||
Type of Target |
Successful |
||||
Drug Potency against Target | GPI-1485 | Drug Info | IC50 = 5 nM | [1] | |
Action against Disease Model | GPI-1485 | Drug Info | Oral dosing in animals with GPI 1485 stimulates significant neuroprotective and neuroregenerative activity in preclinical models of post-prostatectom erectile dysfunction. Treatment with GPI 1485 at the time of injury maintained intracavernosal pressure at near normal levels for up to 28 days after injury. In addition, delayed treatment with GPI 1485 up to seven days after the peripheral nerve injury procedure promoted significant restoration of function, restoring intracavernosal pressure to between 90%-100% of normal levels when measured at one month after injury. | ||
References | |||||
REF 1 | Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):33-8. | ||||
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