Target Validation Information
TTD ID	T72168
Target Name	Mineralocorticoid receptor (MR)
Type of Target	Successful
Drug Potency against Target	AL-43	Drug Info	Ki = 46 nM	[1]
	Epierenone	Drug Info	Ki = 124 nM	[4]
	LG-120838	Drug Info	IC50 < 20 nM	[6]
	LGD-5552	Drug Info	Ki = 149 nM	[3]
	ONAPRISTONE	Drug Info	IC50 = 470 nM	[2]
	WAY-255348	Drug Info	IC50 = 3700 nM	[5]
References
REF 1	Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dih... J Med Chem. 2003 Mar 13;46(6):1016-30.
REF 2	Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8.
REF 3	Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9.
REF 4	(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mine... J Med Chem. 2007 Dec 27;50(26):6443-5.
REF 5	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73.
REF 6	5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists. J Med Chem. 1998 Oct 22;41(22):4354-9.

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