| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T67022 | ||||
| Target Name | Caspase (CASP) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Ac-DEVD-CHO | Drug Info | IC50 = 59.1 nM | [2] | |
| Isoquinoline-1,3,4(2H)-trione | Drug Info | IC50 = 386 nM | [1] | ||
| References | |||||
| REF 1 | Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. | ||||
| REF 2 | Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63. | ||||
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