| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T65291 | ||||
| Target Name | Fatty aldehyde dehydrogenase (ALDH3A2) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Disulfiram | Drug Info | IC50 = 7.5+/-1.2 microM | [1] | |
| Aloe-emodin | Drug Info | IC50 = 6000 nM | |||
| References | |||||
| REF 1 | S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase. Biochem Pharmacol. 1995 Mar 1;49(5):693-700. | ||||
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