Target Validation Information
TTD ID	T64205
Target Name	Signal transducer and activator of transcription 1 (STAT1)
Type of Target	Patented-recorded
Action against Disease Model	Fludarabine	Drug Info	STAT1 (signal transducer and activator of transcription 1) is potentially involved in cell survival, as well as cell death, in different types of cells. The present study was designed to examine the effects of STAT1 on hypoxia/re-oxygenation (H/R)-induced cell death and/or survival, and the underlying mechanisms of any such effects. H/R was shown to induce apoptotic cell death of rat hepatocytes. The addition of a STAT1-specific inhibitor, fludarabine, significantly increased the fraction of apoptotic cells after H/R.	[1]
References
REF 1	Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J. 2004 May 15;380(Pt 1):203-9.

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