Target Validation Information
TTD ID	T63414
Target Name	P2X purinoceptor 7 (P2RX7)
Type of Target	Clinical trial
Drug Potency against Target		Drug Info	IC50 = 10 nM	[1]
	A-740003	Drug Info	IC50 = 18 nM	[1]
	KN-62	Drug Info	IC50 = 110 nM	[2]
	STYLISSADINE A	Drug Info	IC50 = 700 nM	[1]
	STYLISSADINE B	Drug Info	IC50 = 1800 nM	[1]
Action against Disease Model	AZD9056	Drug Info	The P2X7 receptor antagonist AZD9056 has been evaluated in preclinical models of RA with promising results (the results were classified as unpublished in this report)
References
REF 1	Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorg Med Chem. 2009 Jul 15;17(14):4861-5.
REF 2	Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6053-8.

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