Target Validation Information
TTD ID	T62184
Target Name	GABA transporter GAT-1 (SLC6A1)
Type of Target	Successful
Drug Potency against Target	(R)-nipecotic acid	Drug Info	IC50 = 2600 nM	[1]
	(S)-Piperidine-3-carboxylic acid	Drug Info	IC50 = 2660 nM	[1]
	2,4-Diamino-butyric acid(GABA)	Drug Info	IC50 = 2000 nM	[2]
	4-Hydroxy-piperidine-3-carboxylic acid	Drug Info	IC50 = 11000 nM	[3]
	GSK683699	Drug Info	IC50 = 2640 nM	[1]
References
REF 1	Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9.
REF 2	Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9.
REF 3	Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62.

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