Target Validation Information
TTD ID	T61317
Target Name	Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)
Type of Target	Clinical trial
Drug Potency against Target	(-)-CATECHINGALLATE	Drug Info	Ki = 2800 nM	[1]
	2-Hexadecynoic acid	Drug Info	Ki = 6000 nM	[2]
	3,7,3',4'-TETRAHYDROXYFLAVONE	Drug Info	IC50 = 4100 nM	[1]
	Chrysin	Drug Info	IC50 = 10000 nM	[1]
	Epigallocatechin gallate	Drug Info	IC50 = 300 nM	[1]
	GALLOCATECHIN GALLATE	Drug Info	IC50 = 1100 nM	[1]
	ISORHAMNETIN	Drug Info	IC50 = 8300 nM	[1]
	KAEMPFEROL	Drug Info	IC50 = 4000 nM	[1]
	MORIN	Drug Info	IC50 = 2300 nM	[1]
References
REF 1	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
REF 2	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.

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