Target Validation Information
TTD ID T60366
Target Name Ornithine decarboxylase (ODC1)
Type of Target
Successful
Drug Potency against Target Eflornithine Drug Info Ki = 2200???000 nM [4]
1-Amino-3-(aminoxy)-2-propanol Dihydrochloride Drug Info IC50 = 39 nM [3]
3-(Aminooxy)propan-1-amine hydrochloride Drug Info IC50 = 35 nM [3]
3-methoxy-4-hydroxylonchocarpin Drug Info IC50 = 3600 nM [1]
4-hydroxylonchocarpin Drug Info IC50 = 4700 nM [1]
LONCHOCARPUSONE Drug Info IC50 = 2600 nM [1]
ZAPOTIN Drug Info IC50 = 3400 nM [2]
References
REF 1 New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
REF 2 Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
REF 3 Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6.
REF 4 A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog. 2010 Nov 24;6(11):e1001204.

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