Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T60366 | ||||
Target Name | Ornithine decarboxylase (ODC1) | ||||
Type of Target |
Successful |
||||
Drug Potency against Target | Eflornithine | Drug Info | Ki = 2200???000 nM | [4] | |
1-Amino-3-(aminoxy)-2-propanol Dihydrochloride | Drug Info | IC50 = 39 nM | [3] | ||
3-(Aminooxy)propan-1-amine hydrochloride | Drug Info | IC50 = 35 nM | [3] | ||
3-methoxy-4-hydroxylonchocarpin | Drug Info | IC50 = 3600 nM | [1] | ||
4-hydroxylonchocarpin | Drug Info | IC50 = 4700 nM | [1] | ||
LONCHOCARPUSONE | Drug Info | IC50 = 2600 nM | [1] | ||
ZAPOTIN | Drug Info | IC50 = 3400 nM | [2] | ||
References | |||||
REF 1 | New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10. | ||||
REF 2 | Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5. | ||||
REF 3 | Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. | ||||
REF 4 | A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog. 2010 Nov 24;6(11):e1001204. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.