| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T59845 | ||||
| Target Name | Serine/threonine PP1-alpha (PPP1CA) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | CANTHARIDIC_ACID | Drug Info | IC50 = 600 nM | [1] | |
| Cantharidin | Drug Info | IC50 = 500 nM | [1] | ||
| MICROCYSTIN-LR | Drug Info | IC50 = 0.1 nM | [1] | ||
| NORCANTHARIDIN | Drug Info | IC50 = 2832 nM | [2] | ||
| PALASONIN | Drug Info | IC50 = 700 nM | [1] | ||
| TAUTOMYCIN | Drug Info | IC50 = 0.7 nM | [1] | ||
| References | |||||
| REF 1 | Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. | ||||
| REF 2 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | ||||
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