| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T59479 | ||||
| Target Name | Apoptosis-2 messenger RNA (BIRC3 mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | SM-122 | Drug Info | IC50 = 74.7 nM | [2] | |
| SM-131 | Drug Info | Ki = 4.8 nM | [1] | ||
| SM-337 | Drug Info | IC50 = 26.3 nM | [2] | ||
| References | |||||
| REF 1 | Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5. | ||||
| REF 2 | Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7. | ||||
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