Target Validation Information
TTD ID	T59045
Target Name	GABA transaminase (ABAT)
Type of Target	Successful
Drug Potency against Target	L-Alanine	Drug Info	Ki = 160000 nM	[3]
	1-(4-hydroxyphenyl)prop-2-en-1-one	Drug Info	IC50 = 5480 nM	[1]
	3-chloro-1-(4-hydroxyphenyl)propan-1-one	Drug Info	IC50 = 3990 nM	[2]
	4-hydroxy-3-nitrobenzaldehyde	Drug Info	IC50 = 15500 nM	[1]
	4-hydroxybenzaldehyde	Drug Info	IC50 = 16500 nM	[2]
	4-hydroxybenzylamine	Drug Info	IC50 = 15400 nM	[1]
	T83193	Drug Info	IC50 = 17100 nM	[1]
References
REF 1	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
REF 2	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.
REF 3	Inhibitors of glutamine synthetase and their potential application in medicine. Mini Rev Med Chem. 2008 Aug;8(9):869-78.

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