| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T56035 | ||||
| Target Name | cGMP-dependent protein kinase (cGK) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | STAUROSPORINONE | Drug Info | IC50 = 650 nM | ||
| TENELLONE A | Drug Info | IC50 = 12600 nM | [1] | ||
| TENELLONE B | Drug Info | IC50 = 8700 nM | [1] | ||
| References | |||||
| REF 1 | Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611-3. | ||||
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