Target Validation Information
TTD ID	T55729
Target Name	Stress-activated protein kinase 2b (p38 beta)
Type of Target	Clinical trial
Drug Potency against Target	BMS-582949	Drug Info	IC50 = 1.5 nM	[4]
	ML-3163	Drug Info	IC50 = 880 nM	[1]
	ML-3375	Drug Info	IC50 = 1200 nM	[3]
	ML-3403	Drug Info	IC50 = 990 nM	[3]
	RWJ-68354	Drug Info	IC50 = 7 nM	[2]
References
REF 1	From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40.
REF 2	Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50.
REF 3	Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.
REF 4	The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alph... Bioorg Med Chem Lett. 2008 Mar 15;18(6):1762-7.

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