Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T49368 | ||||
Target Name | PKC-delta messenger RNA (PRKCD mRNA) | ||||
Type of Target |
Literature-reported |
||||
Drug Potency against Target | Drug Info | Ki = 1.8 nM | [1] | ||
8-Octyl-benzolactam-V9 | Drug Info | Ki = 216 nM | [3] | ||
BALANOL | Drug Info | IC50 = 30 nM | |||
Bisindolylmaleimide-I | Drug Info | IC50 = 32 nM | [4] | ||
Bryostatin-1 | Drug Info | Ki = 0.44 nM | [5] | ||
Diheptan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info | Ki = 529 nM | [5] | ||
Dihexan-3-yl 5-(hydroxymethyl)isophthalate | Drug Info | Ki = 915 nM | [5] | ||
LY-326449 | Drug Info | IC50 = 690 nM | [6] | ||
PROSTRATIN | Drug Info | Ki = 190 nM | [2] | ||
References | |||||
REF 1 | Protein kinase C modulators bearing dicarba-CLOSO-dodecaborane as a hydrophobic pharmacophore. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2561-4. | ||||
REF 2 | A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. | ||||
REF 3 | Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. | ||||
REF 4 | Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63. | ||||
REF 5 | Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. | ||||
REF 6 | (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. | ||||
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