Target Validation Information
TTD ID T46365
Target Name M-phase inducer phosphatase 2 (MPIP2)
Type of Target
Clinical trial
Drug Potency against Target 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione Drug Info IC50 = 8710 nM [1]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione Drug Info IC50 = 10860 nM [1]
3-isopropyl-4-phenylnaphthalene-1,2-dione Drug Info IC50 = 3230 nM [1]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione Drug Info IC50 = 4530 nM [1]
4-ethoxynaphthalene-1,2-dione Drug Info IC50 = 270 nM [3]
5,6,7,8-tetrahydroanthracene-1,4-dione Drug Info IC50 = 9530 nM [3]
6,7-dibromoquinoline-5,8-dione Drug Info IC50 = 5300 nM [2]
ADOCIAQUINONE B Drug Info IC50 = 70 nM [2]
ANTHRAQUINONE Drug Info IC50 = 9510 nM [3]
Avastin+/-Tarceva Drug Info IC50 = 1980 nM [3]
NSC-95397 Drug Info IC50 = 3770 nM [2]
References
REF 1 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
REF 2 Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9.
REF 3 Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.