| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T41955 | ||||
| Target Name | Long transient receptor potential channel 8 (TRPM8) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | 2-(5-fluoro-1H-indol-3-yl)ethanamine | Drug Info | IC50 = 13100 nM | [1] | |
| 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine | Drug Info | IC50 = 8930 nM | [1] | ||
| 5-Benzyloxytryptamine | Drug Info | IC50 = 660 nM | [1] | ||
| 5-METHOXYTRYPTAMINE | Drug Info | IC50 = 11600 nM | [1] | ||
| References | |||||
| REF 1 | 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. | ||||
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