| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T40694 | ||||
| Target Name | Polo-like kinase 1 (PLK1) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | BI 2536 | Drug Info | IC50 = 0.8 nM | [2] | |
| GSK461364 | Drug Info | IC50 = 2.2 nM | [2] | ||
| Action against Disease Model | BI 2536 | Drug Info | Induced mitotic arrest and apoptosis (IC50 = 2-30 nM) in multiple t uMour cell lines; induced t uMour regression in h uMan colon carcinoma xenografts. | [1] | |
| References | |||||
| REF 1 | Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. | ||||
| REF 2 | End of the line for cannabinoid receptor 1 as an anti-obesity target An opinion. Nat Rev Drug Discov. 2009 Jul;8(7):594. | ||||
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