| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T40111 | ||||
| Target Name | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Ribavirin | Drug Info | IC50 = 500000 nM | [1] | |
| Action against Disease Model | Mizoribine | Drug Info | IC50 on severe acute respiratory syndrome-associated coronavirus Frankfurt-1: 3500 ng/mL | [3] | |
| Ribavirin | Drug Info | IC50 on h uMan adenovirus species C: 77000nM | [2] | ||
| References | |||||
| REF 1 | ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy. Acta Biochim Pol. 2000;47(1):173-80. | ||||
| REF 2 | In vitro susceptibility of adenovirus to antiviral drugs is species-dependent. Antivir Ther. 2005;10(2):225-9. | ||||
| REF 3 | Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus. Antiviral Res. 2005 Jun;66(2-3):159-63. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.