| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T39123 | ||||
| Target Name | G-protein coupled receptor 54 (KISS1R) | ||||
| Type of Target |
Discontinued |
||||
| Drug Potency against Target | 4-fluorobenzoyl-Phe-Gly-Leu-Arg-Trp-NH2 | Drug Info | IC50 = 0.71 nM | [1] | |
| Action against Disease Model | TAK-683 | Drug Info | TAK-683 Hormone regulation on cancer cell line | ||
| References | |||||
| REF 1 | Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase. J Med Chem. 2008 Dec 11;51(23):7645-9. | ||||
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