| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T39087 | ||||
| Target Name | Human immunodeficiency virus Integrase (HIV IN) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Dolutegravir | Drug Info | IC50 = 0.51 nM | [1] | |
| Action against Disease Model | Dolutegravir | Drug Info | GSK1349572 inhibited HIV integrase in an In vitro strand transfer assay. In PBMC cells, the antiviral EC50 and EC90 values were 0.51 and 2.0 nM, respectively. | ||
| References | |||||
| REF 1 | Pharmacokinetics and safety of S/GSK1349572, a next-generation HIV integrase inhibitor, in healthy volunteers. Antimicrob Agents Chemother. 2010 Jan;54(1):254-8. | ||||
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