Target Validation Information
TTD ID	T38996
Target Name	Phospholipase D1 (PLD1)
Type of Target	Patented-recorded
Drug Potency against Target	1-(pyridin-2-yl)piperazine	Drug Info	IC50 = 3600 nM	[2]
	1-(pyridin-4-yl)piperazine	Drug Info	IC50 = 3600 nM	[2]
	Afimoxifene	Drug Info	IC50 = 4800 nM	[1]
	HALOPEMIDE	Drug Info	IC50 = 21 nM	[1]
References
REF 1	Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.
REF 2	Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privil... Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3.

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