| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T37808 | ||||
| Target Name | Atrial natriuretic peptide receptor B (NPR2) | ||||
| Type of Target |
Clinical trial |
||||
| Action against Disease Model | Cenderitide | Drug Info | CD-NP in vitro activates cyclic guanosine monophosphate and inhibits cardiac fibroblast proliferation. CD-NP in vivo is natriuretic and diuretic, glomerular filtration rate enhancing, cardiac unloading, and renin inhibiting | [1] | |
| References | |||||
| REF 1 | Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP. J Am Coll Cardiol. 2008 Jul 1;52(1):60-8. | ||||
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