| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T37510 | ||||
| Target Name | Coagulation factor Va (F5) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Drotrecogin alfa | Drug Info | IC50 = 12.8 nM | [2] | |
| RAZAXABAN | Drug Info | Ki = 19700 nM | [1] | ||
| References | |||||
| REF 1 | Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1795-8. | ||||
| REF 2 | Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009 May;40(5):1864-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.