| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T35640 | ||||
| Target Name | Integrin alpha-L (ITGAL) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | A-286982 | Drug Info | IC50 = 44 nM | [2] | |
| BMS-587101 | Drug Info | IC50 = 150 nM | [1] | ||
| References | |||||
| REF 1 | Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-(... J Med Chem. 2010 May 13;53(9):3814-30. | ||||
| REF 2 | Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. | ||||
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