Target Validation Information
TTD ID	T30081
Target Name	Thymidine kinase 1 (TK1)
Type of Target	Successful
Drug Potency against Target	1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine	Drug Info	Ki = 500 nM	[1]
	1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine	Drug Info	IC50 = 9700 nM	[1]
	1-[5-(triphenylmethoxy)pentyl]thymine	Drug Info	IC50 = 2500 nM	[1]
	1-[6-(triphenylmethoxy)hexyl]thymine	Drug Info	IC50 = 500 nM	[1]
	1-[7-(triphenylmethoxy)heptyl]thymine	Drug Info	IC50 = 4700 nM	[1]
	2-phenylamino-9-(4-hydroxy-butyl)-6-oxopurine	Drug Info	IC50 = 11500 nM	[2]
	3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine	Drug Info	IC50 = 4700 nM	[3]
	5-propyl-2'-deoxyuridine	Drug Info	IC50 = 4200 nM	[2]
	Edoxudine	Drug Info	IC50 = 150 nM	[2]
	L-5-(bromovinyl)deoxyuridine	Drug Info	IC50 = 15000 nM	[2]
	L-5-iodo-2'-deoxyuridine	Drug Info	IC50 = 2000 nM	[2]
	N2-(3-trifluoromethylphenyl)guanine	Drug Info	IC50 = 3500 nM	[2]
References
REF 1	N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73.
REF 2	Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34.
REF 3	3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2010 Apr 8;53(7):2902-12.

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