Target Validation Information
TTD ID	T28869
Target Name	Bacterial Urease (Bact ureC)
Type of Target	Successful
Drug Potency against Target	1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea	Drug Info	Ki = 25 nM	[1]
	3-(4-bromobenzyl)-1,1-dimethylselenourea	Drug Info	Ki = 135 nM	[1]
	3-(4-bromophenyl)-1,1-dimethylthiourea	Drug Info	Ki = 255 nM	[1]
	3-dodecyl-1,1-dimethylthiourea	Drug Info	Ki = 124 nM	[1]
	N-glycylglycinehydroxamic acid	Drug Info	IC50 = 790 nM	[2]
References
REF 1	Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91.
REF 2	Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem. 2008 Sep 25;51(18):5736-44.

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