| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T28705 | ||||
| Target Name | Caspase 8 messenger RNA (CASP8 mRNA) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | Acetyl-Ile-Glu-Thr-Asp-aldehyde | Drug Info | IC50 = 4.2 nM | [3] | |
| Isoquinoline-1,3,4(2H)-trione | Drug Info | IC50 = 1910 nM | [1] | ||
| PRALNACASAN | Drug Info | IC50 = 40 nM | [2] | ||
| References | |||||
| REF 1 | Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. | ||||
| REF 2 | Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4728-32. | ||||
| REF 3 | Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91. | ||||
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