Target Validation Information
TTD ID	T25889
Target Name	Adenylate cyclase (ADCY)
Type of Target	Literature-reported
Drug Potency against Target	2,5-didesoxy-3-ATP	Drug Info	IC50 = 700 nM	[3]
	2-hydroxy-17beta-estradiol	Drug Info	IC50 = 3000 nM	[3]
	DEOXYADENOSINE	Drug Info	IC50 = 15000 nM	[1]
	N6-CYCLOPENTYLADENOSINE	Drug Info	IC50 = 3200 nM	[2]
	NSC-270718	Drug Info	IC50 = 11000 nM	[3]
	NSC-88915	Drug Info	IC50 = 1100 nM	[3]
References
REF 1	Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.
REF 2	Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
REF 3	Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.