Target Validation Information
TTD ID	T25703
Target Name	Heme oxygenase 1 (HMOX1)
Type of Target	Clinical trial
Drug Potency against Target	AZALANSTAT	Drug Info	IC50 = 5300 nM	[1]
Action against Disease Model	Stannsoporfin	Drug Info	Studies in vitro, in animal models, and in adult and newborn h uMans have demonstrated that certain tin(Sn)-porphyrins competitively inhibit the activity of heme oxygenase (the rate-limiting enzyme in heme catabolism), reduce production of bilirubin and can thereby substantially diminish plasma levels of the bile pigment	[2]
References
REF 1	Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem. 2007 May 1;15(9):3225-34.
REF 2	Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin. Pediatrics. 1994 Jan;93(1):1-11.

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