Target Validation Information
TTD ID	T25258
Target Name	Multidrug resistance protein 1 (ABCB1)
Type of Target	Clinical trial
Drug Potency against Target	4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl	Drug Info	IC50 = 16000 nM	[1]
	6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol	Drug Info	IC50 = 16000 nM	[1]
	Elacridar	Drug Info	IC50 = 2000 nM	[3]
	TRISMETHOXYRESVERATROL	Drug Info	IC50 = 8000 nM	[1]
	XR-9456	Drug Info	IC50 = 300 nM	[2]
	XR-9504	Drug Info	IC50 = 260 nM	[2]
	XR-9544	Drug Info	IC50 = 50 nM	[2]
	XR-9577	Drug Info	IC50 = 320 nM	[2]
	[1,1':2',1'']-terphenyl-4,3'',5''-triol	Drug Info	IC50 = 12000 nM	[1]
References
REF 1	Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8.
REF 2	Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62.
REF 3	2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. J Med Chem. 2008 Dec 11;51(23):7602-13.

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