| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T24634 | ||||
| Target Name | Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Fosfomycin | Drug Info | IC50 = 100 nM | [2] | |
| CYNAROPICRIN | Drug Info | IC50 = 12100 nM | [1] | ||
| EUPATORIOPICRIN | Drug Info | IC50 = 19800 nM | [1] | ||
| References | |||||
| REF 1 | Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. | ||||
| REF 2 | Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5757-62. | ||||
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