Target Validation Information
TTD ID	T19923
Target Name	Bcl-x messenger RNA (BCL2L1 mRNA)
Type of Target	Literature-reported
Drug Potency against Target	4,5-dibenzylbenzene-1,2-diol	Drug Info	IC50 = 8500 nM	[4]
	PURPUROGALLIN	Drug Info	IC50 = 2200 nM	[1]
	QEDIIRNIARHLAQVGDSMDR	Drug Info	Ki = 7 nM	[2]
	TW-37	Drug Info	Ki = 1110 nM	[3]
References
REF 1	Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64.
REF 2	Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.
REF 3	Fragment-based deconstruction of Bcl-xL inhibitors. J Med Chem. 2010 Mar 25;53(6):2577-88.
REF 4	Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906.

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