Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T17980 | ||||
Target Name | Fyn tyrosine protein kinase (FYN) | ||||
Type of Target |
Successful |
||||
Drug Potency against Target | Dasatinib | Drug Info | Kd = 0.79 nM | [4] | |
CEP-5104 | Drug Info | IC50 = 3400 nM | [3] | ||
CEP-6331 | Drug Info | IC50 = 1190 nM | [3] | ||
JNJ-10198409 | Drug Info | IC50 = 378 nM | [1] | ||
Ro-4396686 | Drug Info | IC50 = 466 nM | [2] | ||
References | |||||
REF 1 | (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. | ||||
REF 2 | Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. | ||||
REF 3 | Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. | ||||
REF 4 | A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008 Jan;26(1):127-32. | ||||
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