Target Validation Information
TTD ID	T16868
Target Name	Neural cadherin (CDH2)
Type of Target	Clinical trial
Drug Potency against Target	Exherin	Drug Info	IC50 = 2330 nM	[2]
Action against Disease Model	Exherin	Drug Info	A cyclic peptide, Exherin (N-Ac-CHAVC-NH2) can perturb cadherin-mediated endothelial cell interactions, resulting in a progressive apoptotic cell death. This effect depends on cell density, as it is only observed when dense cultures are treated with the peptide. Adherens junction (AJ)-associated cadherin and catenins are differentially affected by the Exherin treatment, as judged by double immunofluorescence labeling followed by immunofluorescence-ratio imaging.	[1]
References
REF 1	Induction of apoptosis in cultured endothelial cells by a cadherin antagonist peptide: involvement of fibroblast growth factor receptor-mediated signalling. Exp Cell Res. 2004 Apr 1;294(2):366-78.
REF 2	Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion. Peptides. 2009 Dec;30(12):2380-7.

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